Virag L, Scott GS, Antal-Szalmas P, O'Connor M, Ohshima H, Szabo C. Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase activation and cytotoxicity. Mol Pharmacol. 1999 Oct;56(4):824-33.

Whalen MJ, Clark RS, Dixon CE, Robichaud P, Marion DW, Vagni V, Graham SH, Virag L, Hasko G, Stachlewitz R, Szabo C, Kochanek PM. Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab. 1999 Aug;19(8):835-42.

Virag L, Szabo C. Inhibition of poly(ADP-ribose) synthetase (PARS) and protection against peroxynitrite-induced cytotoxicity by zinc chelation. Br J Pharmacol. 1999 Feb;126(3):769-77.

Ajuebor MN, Das AM, Virag L, Szab, Perretti M. Regulation of macrophage inflammatory protein-1 alpha expression and function by endogenous interleukin-10 in a model of acute inflammation. Biochem Biophys Res Commun. 1999 Feb 16;255(2):279-82.

Ajuebor MN, Das AM, Virag L, Flower RJ, Szabo C, Perretti M. Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10. J Immunol. 1999 Feb 1;162(3):1685-91.

Virag L, Szabo C. BCL-2 protects peroxynitrite-treated thymocytes from poly(ADP-ribose) synthase (PARS)-independent apoptotic but not from PARS-mediated necrotic cell death. Free Radic Biol Med. 2000 Oct 15;29(8):704-13.

Whalen MJ, Clark RS, Dixon CE, Robichaud P, Marion DW, Vagni V, Graham S, Virag L, Hasko G, Stachlewitz R, Szabo C, Kochanek PM. Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report. Acta Neurochir Suppl. 2000;76:61-4.

Liaudet L, Soriano FG, Szabo E, Virag L, Mabley JG, Salzman AL, Szabo C. Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10203-8.

Hasko G, Kuhel DG, Nemeth ZH, Mabley JG, Stachlewitz RF, Virag L, Lohinai Z, Southan GJ, Salzman AL, Szabo C. Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock. J Immunol. 2000 Jan 15;164(2):1013-9.

Bai P, Bakondi E, Szabo E, Gergely P, Szabo C, Virag L. Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxity in thymocytes. Free Radic Biol Med. 2001 Dec 15;31(12):1616-23.

Mabley JG, Jagtap P, Perretti M, Getting SJ, Salzman AL, Virag L, Szabo E, Soriano FG, Liaudet L, Abdelkarim GE, Hasko G, Marton A, Southan GJ, Szabo C. Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflamm Res. 2001 Nov;50(11):561-9.

Soriano FG, Virag L, Szabo C. Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation. J Mol Med. 2001 Aug;79(8):437-48. Review.

Liaudet L, Szabo E, Timashpolsky L, Virag L, Cziraki A, Szabo C. Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences. Br J Pharmacol. 2001 Aug;133(8):1424-30.

Szabo E, Virag L, Bakondi E, Gyure L, Hasko G, Bai P, Hunyadi J, Gergely P, Szabo C. Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity. J Invest Dermatol. 2001 Jul;117(1):74-80.

Scott GS, Hake P, Kean RB, Virag L, Szabo C, Hooper DC. Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis. J Neuroimmunol. 2001 Jul 2;117(1-2):78-86.

Lohinai Z, Stachlewitz R, Virag L, Szekely AD, Hasko G, Szabo C. Evidence for reactive nitrogen species formation in the gingivomucosal tissue. J Dent Res. 2001 Feb;80(2):470-5.

Soejima K, Traber LD, Schmalstieg FC, Hawkins H, Jodoin JM, Szabo C, Szabo E, Virag L, Salzman A, Traber DL. Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury. Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):745-52.

Virag L, Szabo C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107.

Eaves-Pyles T, Murthy K, Liaudet L, Virag L, Ross G, Soriano FG, Szabo C, Salzman AL. Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction. J Immunol. 2001 Jan 15;166(2):1248-60.

Soriano GF, Virag L, Jagtap P, Szabo E, Mabley JG, Liaudet L, Marton A, Hoyt DG, Murthy KG, Salzman AL, Southan GJ, Szabo C. Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med. 2001 Jan;7(1):108-13.

Szabó C, Mabley JG, Moeller SM, Shimanovich R, Pacher P, Virág L, Soriano FG, Van Duzer JH, Williams W, Salzman AL, and GrovesJT. Pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst. Molecular Medicine 8.10 (2002) 571-580

Kirov MY, Evgenov OV, Kuklin VN, Virag L, Pacher P, Southan GJ, Salzman AL, Szabo C, Bjertnaes LJ. Aerosolized Linear Polyethylenimine-Nitric Oxide/Nucleophile Adduct Attenuates Endotoxin-induced Lung Injury in Sheep. Am J Respir Crit Care Med 2002 Dec 1;166(11):1436-42

Virág L and Szabó C: The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacological Reviews 54:375- 429, 2002.

Virág L, Szabó É, Bakondi E, Bai P, Gergely P, Hunyadi J, Szabó C: The nitric oxide - peroxynitrite - poly(ADP-ribose) polymerase pathway in the skin (Minireview) Exp. Dermatol. 11:189-202, 2002.

Goldfarb RD, Marton A, Szabó E, Virág L, Salzman AL, Glock D, Akhter I, McCarthy R, Parrillo JE, Szabó C. Protective effect of a novel, potent inhibitor of poly(adenosine 5’-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis. Crit. Care. Med 30:974-980, 2002

Jagtap P, Soriano FG, Virág L, Liaudet L, Mabley J, Szabó E, Haskó G, Marton A, Lorigados CB, Gallyas F. Jr, Sümegi B, Hoyt DG, Baloglu E, VanDuzer J, Salzman AL, Southan, GJ, Szabó C. Novel phenanthridinone inhibitors of poly (adenosine 5’-diphosphate-ribose) synthetase: Potent cytoprotective and antishock agents. Crit. Care. Med 30: 1071-1082, 2002

Soriano FG, Liaudet L, Szabo E, Virág L, Mabley JG, Pacher P, Szabó C: Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice. Shock 17(4):286-92, 2002

Pacher P, Liaudet L, Bai P, Virág L, Mabley J, Haskó G, Szabó C: Activation of poly(ADP-ribose) polymerase contributes to the development of doxorubicin-induced heart failure. J. Pharmacol. Exp. Therap. 300(3):862-7, 2002.

Faro R, Toyoda Y, McCully JD, Jagtap P, Szabó E, Virág L, Bianchi C, Levitsky S, Szabó C, and Sellke FW Myocardial protection by PJ34, a novel potent poly (ADP-ribose) synthetase inhibitor. Ann. Thor. Surg. 73(2):575-581, 2002.

Liaudet L, Pacher P, Mabley JG, Virag L, Soriano FG, Hasko G, Szabo C. Activation of Poly(ADP-Ribose) Polymerase-1 Is a Central Mechanism of Lipopolysaccharide-Induced Acute Lung Inflammation. Am J Respir Crit Care Med. 2002 Feb 1;165(3):372-377.

Bakondi E, Bai P, Szabo E E, Hunyadi J, Gergely P, Szabo C, Virag L. Detection of poly(ADP-ribose) polymerase activation in oxidatively stressed cells and tissues using biotinylated NAD substrate. J Histochem Cytochem. 2002 Jan;50(1):91-8.

Németh ZH, Leibovich J, Deitch EA, Sperlágh B, Virág L, Vízi SE, Szabó C, Haskó G: Adenosine stimulates CREB activation in macrophages via p38 MAPK-mediated mechanism. Biochem. Biophys. Res. Commun. 312(4):883-8, 2003.

Bakondi E, Gönczi M, Szabó É, Bai P, Pacher P, Gergely P, Kovács L, Hunyadi J, Szabó C, Csernoch L, Virág L. Role of intracellular calcium mobilization and cell density-dependent signaling in oxidative stress-induced cytotoxicity in HaCaT keratinocytes. J. Invest. Dermatol. 121:88-95, 2003.

Virág L, Szabó É, Gergely P, Szabó C: Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicology Letters, Volumes 140-141:113-124, 2003.

Pacher P, Liaudet L, Bai P, Mabley JG, Kaminski PM, Virág L, Deb A, Szabó É, Ungvári Z, Wolin MS, Szabó C.A potent peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation 107:896-904

Liaudet L, Szabó C, Evgenov O, Murthy KG, Pacher P, Virág L, Mabley J, Marton A, Soriano FG, Kirov M, Bjertnaes LJ, Salzman AL (2003) Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis. Shock, 19: 131-137.

Scott GS, Virag L, Szabo C, Hooper DC. Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation. Glia 2003 Jan 15;41(2):105-116

Németh ZH, Leibovich J, Deitch EA, Sperlágh B, Virág L, Vízi SE, Szabó C, Haskó G: Adenosine stimulates CREB activation in macrophages via p38 MAPK-mediated mechanism. Biochem. Biophys. Res. Commun. 312(4):883-8, 2003.

Bakondi E, Gönczi M, Szabó É, Bai P, Pacher P, Gergely P, Kovács L, Hunyadi J, Szabó C, Csernoch L, Virág L. Role of intracellular calcium mobilization and cell density-dependent signaling in oxidative stress-induced cytotoxicity in HaCaT keratinocytes. J. Invest. Dermatol. 121:88-95, 2003.

Virág L, Szabó É, Gergely P, Szabó C: Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicology Letters, Volumes 140-141:113-124, 2003.

Pacher P, Liaudet L, Bai P, Mabley JG, Kaminski PM, Virág L, Deb A, Szabó É, Ungvári Z, Wolin MS, Szabó C.A potent peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation 107:896-904

Liaudet L, Szabó C, Evgenov O, Murthy KG, Pacher P, Virág L, Mabley J, Marton A, Soriano FG, Kirov M, Bjertnaes LJ, Salzman AL (2003) Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis. Shock, 19: 131-137.

Scott GS, Virag L, Szabo C, Hooper DC. Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation. Glia 2003 Jan 15;41(2):105-116

Related documents

Animation

User login